Effexor (venlafaxine) is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in several mental disorders. It is believed to work by increasing levels of serotonin and norepinephrine in the brain, responsible for mood regulation.

Patients most commonly buy Effexor to manage:

• Major Depressive Disorder
• Generalized Anxiety Disorder
• Social Anxiety Disorder
• Panic Disorder

Though generally not the preferred treatment in other psychiatric conditions, Effexor is sometimes used when preferred treatments fail to produce significant results.

Some patients buy Effexor for off-label use in managing chronic nerve pain, provided there is no risk of interaction with other medications being taken; it may help alleviate pain as well as treat the depression that often accompanies living with chronic pain.

What to Expect from Effexor

Treatment with Effexor is similar in all conditions, though dosage may need to be lowered depending on other medications being taken, other medical conditions present, age, weight, and other individual variables. In otherwise healthy adults treatment typically consists of:

• Treatment usually starts with 37.5 to 75 mg per day.
• If the initial dose does not produce significant results, dosage may be increased in 75 mg increments every four days, up to 225 mg per day.
• Most patients find 75 to 150 mg sufficient. Doses greater than 225 mg per day are very unusual outside of hospital settings.
• The total daily dose should be divided into 2 or 3 smaller doses, evenly spaced throughout the day.
• Tablets should be taken with food.
• Treatment may continue for as long as it continues to provide benefit.

Treatment with this medication is usually long term, often spanning years. This product is also available in an extended-release (XR) formula, taken just once per day, which may be more convenient than taking multiple daily doses over the long term. Some people have better results with multiple daily doses of regular tablets, however. Patients who have difficulty swallowing whole tablets may want to buy Effexor XR capsules, as they can be opened and sprinkled in food.

It takes a few weeks of treatment for full benefits to be felt. Most patients find the medication improves and stabilizes mood, increases energy levels, promotes focused and clear thinking, and decreases anxiety.

Precautions & Side Effects

The most common side effects from Effexor are usually mild and often stop occurring as the body adjusts to treatment, including:

• Nausea
• Drowsiness
• Dizziness
• Dry mouth
• Appetite loss
• Constipation
• Insomnia
• Sweating

Effexor can interact with a wide range of other medications, both prescription and over-the-counter. Some of these interactions are potentially serious; patients are strongly encouraged to consult a doctor or pharmacist about the safety of mixing medications.

In younger patients under 24 years of age, SNRIs sometimes have a paradoxical effect of worsening mental disorders in the first few weeks of treatment. Symptoms include increased anxiety or depression, suicidal thoughts, agitation, irritability, aggressiveness, hyperactivity, and self-harm. Younger patients should be monitored closely for the first few weeks of treatment. These effects are very unlikely in older patients.

Treatment with any SNRI should not end abruptly; withdrawal symptoms can be very disruptive, including headaches, severe nausea, sweating, difficulty balancing, dizziness, difficulty sleeping, and, in rare cases, hallucinations. Speak with a doctor about a discontinuation plan; dosage should be gradually lowered over several weeks.

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